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dc.creatorLiu, Tsunglin
dc.creatorBundschuh, Ralf
dc.identifier.citationTsunglin Liu, Ralf Bundschuh, "Model for Codon Position Bias in RNA Editing," Physical Review Letters 95, no. 8 (2005), doi:10.1103/PhysRevLett.95.088101en_US
dc.description.abstractRNA editing can be crucial for the expression of genetic information via inserting, deleting, or substituting a few nucleotides at specific positions in an RNA sequence. Within coding regions in an RNA sequence, editing usually occurs with a certain bias in choosing the positions of the editing sites. In the mitochondrial genes of Physarum polycephalum, many more editing events have been observed at the third codon position than at the first and second, while in some plant mitochondria the second codon position dominates. Here we propose an evolutionary model that explains this bias as the basis of selection at the protein level. The model predicts a distribution of the three positions rather close to the experimental observation in Physarum. This suggests that the codon position bias in Physarum is mainly a consequence of selection at the protein level.en_US
dc.publisherAmerican Physical Societyen_US
dc.rights© 2005 The American Physical Societyen_US
dc.titleModel for Codon Position Bias in RNA Editingen_US

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