SPECT Imaging for Temporal Dynamics of Thyroidal and Salivary Radionuclide Accumulation in 17-AAG Treated Thyroid Cancer Mouse Model
Advisor:Jhiang, Sissy M.
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Series/Report no.:2010 Edward F. Hayes Graduate Research Forum. 24th
Selective iodide uptake and prolonged iodine retention in the thyroid is the basis for targeted radioiodine therapy for thyroid cancer patients, however, salivary gland dysfunction is the most frequent non-thyroidal complications. In this study we employed non-invasive SPECT functional imaging to quantify the temporal dynamics of thyroidal and salivary radioiodine accumulation in mice. At 60 min post radionuclide injection, radionuclide accumulation in the salivary gland was generally higher than that in thyroid due to much larger volume of the salivary gland. However, radionuclide accumulation per anatomic unit in the salivary gland was lower than that in thyroid and was comparable among mice of different age and gender. Differently, radionuclide accumulation per anatomic unit in thyroid varied greatly among mice. The extent of thyroidal radioiodine accumulation stimulated by a single dose of exogenous bovine TSH (bTSH) in T3-supplemented mice was much less than that in mice received neither bTSH nor T3 (non-treated mice), suggesting that the duration of elevated serum TSH level is important to maximize thyroidal radioiodine accumulation. Furthermore, the extent and duration of radioiodine accumulation stimulated by bTSH was less in the thyroids of the thyroid-targeted RET/PTC1 (Tg-PTC1) mice bearing thyroid tumors compared to the thyroids in wild type mice. Lastly, the effect of 17-AAG on increasing thyroidal, but not salivary, radioiodine accumulation was validated in both wild type mice and Tg-PTC1 preclinical thyroid cancer mouse model.
Biological Sciences: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)
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