Rapid phase-modulated water-excitation steady-state free precession for fat-suppressed cine cardiovascular MR
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Citation:Lin, Hung Y., Raman, Subha, Chung, Yiu C., Simonetti, Orlando. "Rapid phase-modulated water-excitation steady-state free precession for fat-suppressed cine cardiovascular MR," Journal of Cardiovascular Magnetic Resonance v10, n22 (May, 2008)
BACKGROUND:The purpose of this article is to describe a steady-state free precession (SSFP) sequence for fat-suppressed cine cardiovascular magnetic resonance (CMR). A rapid phase-modulated binomial water-excitation (WE) pulse is utilized to minimize repetition time and acquisition time.METHODS:Three different water-excitation pulses were combined with cine-SSFP for evaluation. The frequency response of each sequence was simulated and examined in phantom imaging studies. The ratio of fat to water signal amplitude was measured in phantoms to evaluate the fat-suppression capabilities of each method. Six volunteers underwent CMR of the heart at 1.5T to compare retrospectively-gated cine-SSFP with and without water-excitation. The ratio of fat to myocardium signal amplitude was measured for conventional cine-SSFP and phase-modulated WE-SSFP. The proposed WE-SSFP method was tested in one patient referred for CMR to characterize a cardiac mass.RESULTS AND DISCUSSION:The measured frequency response in a phantom corresponded to the numerical Bloch equation simulation demonstrating the widened stop-band around the fat resonant frequency for all water-excitation pulses tested. In vivo measurements demonstrated that a rapid, phase-modulated water-excitation pulse significantly reduced the signal amplitude ratio of fat to myocardium from 6.92 +/- 2.9 to 0.8 +/- 0.13 (mean +/- SD) without inducing any perceptible artifacts in SSFP cine CMR.CONCLUSION:fat-suppression can be achieved in SSFP cine CMR while maintaining steady-state equilibrium using rapid, phase modulated, binomial water-excitation pulses.
OPS and SVR receive research support from Siemens Healthcare, Inc., and Y–CC is an employee of Siemens Healthcare, Inc.