Brain tissue: Analysis of mechanical properties
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Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Mechanical Engineering Honors Theses; 2010
The overall research was conducted to better understand the mechanical behavior of brain tissue. My portion of the research specifically examined the difference of mechanical properties for stored versus fresh brain tissue. The goal was to determine a way to compare data from stored brain tissue to fresh brain tissue and to establish a correlation between the data. It was important to better understand the mechanical properties of brain tissue because, provided a better understanding, new strides could be taken to better understand the reaction of the brain with possible biocompatible implants. Fresh brain tissue was provided from a species of monkey (Macaque), which was used for a majority of the experiments and was compared to stored human brain tissue. Tests were conducted on the brain tissue using varied strains and strain rates. For a variety of these tests hyperelastic/viscoelastic models were constructed to mimic the tissue response to strains. Results showed that stored tissue was stiffer when compared with fresh tissue, but have similarly shape stress-strain curves. Results also suggested that with a larger sample data, there could possibly be a correlation drawn between stored and fresh tissue samples. These results have important implications because fresh brain tissue is difficult to attain and work with. Prefaced by Dr. Rebecca Dupaix
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