T wave Spectral Analysis As A Marker For An Increased Risk Of Sudden Cardiac Death Using an in vivo Canine Model
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Publisher:The Ohio State University
Series/Report no.:The Ohio State University. Department of Electrical and Computer Engineering Honors Theses; 2008
300,000 to 500,000 annual deaths in the United States are attributed to sudden cardiac failure . While remaining the leading cause of death in industrially developing countries, effective diagnosis remains an elusive target. From canine data collected over the last 25 years, many models of sudden cardiac death have been useful in analyzing and identifying ventricular fibrillation (VF). This comprehensive and complete data set, along with each dog’s continuous electrocardiogram (EKG), shown in Figure 1, has provided many canine cases that were either susceptible or resistant to VF. Provided these data, along with knowledge of each dog’s susceptibility to VF, an analysis of the dog’s EKG T-wave (TW) variance will provide a noninvasive, quick and effective method for determining a canine’s susceptibility to VF. This knowledge can then be applied in other aspects of diagnosis and treatment ranging from future anti-arrhythmic drug development to a less costly, more effective, internal defibrillator along with simpler methods of identifying patients at risk of cardiac disease and tailoring an appropriate therapy .
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