Effect of Sustained Hand Grip Isometric Exercise on the Response of Erythrocyte 2,3-diphosphoglycerate in Untrained Men
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Citation:The Ohio Journal of Science. v95, n5 (December, 1995), 331-334
Experiments were designed to examine the role of erythrocyte 2,3-diphosphoglycerate (2,3-DPG) in a purely isometric exercise (hand-grip dynamometer) using the human arm as an in vivo model, since the literature contains very little information concerning the contribution of this phosphate in such exercise. 2,3-DPG provides a compensatory adjustment to facilitate oxygen delivery during hypoxic conditions. Its breakdown occurs under acidosis. Twelve untrained males, age ranging from 19 to 22 years, exercised using a hand-grip dynamometer at a sustained contraction of load greater than 50% of their individual maximal voluntary contractions (MVC) until exhaustion occurred between 1.8-3.2 min. There were no significant post-exercise changes in the mean levels of 2,3-DPG when measured as either |imolml * red blood cell (RBC) or mol-mol1 hemoglobin (Hb) immediately after exercise and 50 min after exercise even though immediate post-exercise increase in mean lactate levels and decrease in mean pH levels were significant (P <0.001). It is concluded that the duration of exercise in the present study was too brief for acidosis to affect 2,3-DPG metabolism.
Author Institution: Department of Biology, University of Dayton
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