The Effects of Crocetin on Plasma Lipids in Rats
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Citation:The Ohio Journal of Science. v85, n3 (June, 1985), 97-101
The caroteroid compound, crocetin, has been shown to lower plasma lipid levels in previous animal studies. In this investigation the total cholesterol, HDL cholesterol and total triglyceride levels were monitored in rats fed two different hyperlipemic diets for either 22 or 168 d depending on the diet. Injections of crocetin via subcutaneous and intraperitoneal routes were compared. No significant hypolipemic action was observed for any of the groups receiving crocetin injections in this study. The results clearly show that subcutaneous injections of crocetin in rats do not lower plasma lipid levels. Since crocetin has been shown to lower plasma lipid levels in rats given intraperitoneal injections of crocetin, hepatic activation or higher blood concentrations of the drug is apparently required in rats. The results also suggest that the mechanism responsible for crocetin's physiological activity is different in rats and rabbits.
Author Institution: Department of Chemistry, Ohio Wesleyan University
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