Combination Therapy of Viral Leukemia: Statolon, Radiation and Transplantation
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Citation:The Ohio Journal of Science. v80, n4 (July, 1980), 168-174
Studies were carried out to determine the effectiveness of treating murine viral leukemia by combining statolon therapy with irradiation and transplantation therapy. The experimental design involved inoculating Rauscher leukemia-infected mice with statolon, a potent interferon inducer, prior to lethal whole-body irradiation and following hematopoietic cell transplantation. The data show that treating the leukemic animals in this manner resulted in positive responses from all indices of leukemia development investigated. These responses included a 42% decrease in spleen weight at autopsy, a 21% increase in survival at 30 days, and significantly decreased white blood cell counts and spleen weight during the treatment period. Although the effect of the combination therapy was not permanent and further refinement of the experimental protocol is necessary, it appears to be a promising method of treating viral leukemia.
Author Institution: Celluar and Radiation Biology Laboratories, Clinical Radiation Therapy Research Center, Division of Radiology, Allegheny General Hospital
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