A Sex Difference in the Mortality Pattern of L 1210 Leukemia in DBA/2 Mice

Abstract

Female DBA/2 mice inoculated with 1 x 106 L 1210 leukemia cells died, more rapidly than simultaneously inoculated male mice with a mean survival of 0.1 ± 0.2 days vs. 7.2 =•=0.4 days. For males, this represents an average of 18% longer survival than females. Trials involving gonadectomy or treatment with exogenous sex hormones suggest that the sex difference in mortality was due to exacerbation of L 1210 leukemia by estrogen.