Granulocytic Colony Stimulating Activity in Plasma and Leukocytes from Chronic Myelogenous Leukemia Patients
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Citation:The Ohio Journal of Science. v76, n6 (November, 1976), 274-278
Colony stimulating activity present in plasma and in leukocytes from chronic myelogenous leukemia patients and from normal volunteers was determined by double layer bone-marrow tissue culture. Plasma and leukocytes incorporated into the bottom feeder layer stimulated the formation of colonies from human bone-marrow cells cultured in the upper semi-solid agar layer. The colony stimulating activity of plasma from chronic myelogenous leukemia patients was significantly increased over that of normal plasma (p<.01). The difference between the colony stimulating activity of chonic myelogenous leukemia and normal leukocytes was not statistically significant. After 14 days of incubation, all bone-marrow cell colonies were composed primarily of macrophages rather than granulocytes as had been previously reported.
Author Institution: Leukemia Research Laboratory, Department of Biological Sciences, Bowling Green State University
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