Pharmacy Undergraduate Research Theses and Honors Research Theses: Recent submissions
Now showing results 1-5 of 30
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A Substituted Indole Scaffold as a Class of Allosteric HIV-1 Integrase Inhibitor
Bockbrader, Ross H. ( 2019-12 )Although a number of drugs have been developed and approved to combat HIV over the past 40 years, mutations of the virus and its protein targets have necessitated the continued discovery and design of even more novel ... -
D-RING MODIFICATIONS OF THE PHYLLANTHUSMIN CLASS OF ARYLNAPHTHALENE LIGNAN NATURAL PRODUCTS
Ho, Aimee ( 2019-05 )Natural products isolated from plants of the Phyllanthus genus, specifically members of the arylnaphthalene subclass of lignan lactones, show promise as a potential treatment option for ovarian cancer. These compounds are ... -
Novel Selective Estrogen Receptor Modulator (SERM) OSU-ERβ-12 Demonstrates Anti-fibrotic Efficacy
Klein, Abigail ( 2020-12 )Purpose: Based on demonstrated ERβ-selective transcriptional activity in a cellular model, it was hypothesized that in vivo, efficacious doses of the novel ERβ agonist OSU-ERβ-12 could be determined that have minimal ... -
Antibiotic Efficacy in Treating Variant Pseudomonas aeruginosa and Staphylococcus aureus Biofilms
Li, Anthony ( 2019-05 )This study investigates antibiotic efficacy against planktonic vs biofilm bacteria in vitro, using eight different antibiotics: carbenicillin, ciprofloxacin, colistin, gentamicin, meropenem, rifampicin, tobramycin, and ... -
Characterization of microRNAs as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Etoposide (VP-16) Resistant K562 Cells.
Kania, Evan ( 2019-05 )The enzyme DNA topoisomerase IIα (TOP2α) induces covalent complexes with DNA and produces transient double-strand DNA breaks crucial for processes such as replication and normal chromosomal dysjunction at mitosis. TOP2α ...