Texaphyrins are a synthetic class of porphyrin analogues that contain a metal atom complexed at their centers. This class of compounds selectively accumulates in cancer cells, thus creating a promising opportunity for ...

Abstract: Native chemical ligation (NCL) is a method used to synthesize a covalent bond between two proteins. The method has been extensively used to react a C-terminal thioester on one protein with an N-terminal cysteine ...

Watercress, Nasturtium officinale W.T. Aiton, a member of the Brassicaceae family[1], is highly consumed in salad mixes and contains many phytochemicals[2]. As part of the cancer chemoprevention drug discovery program, ...

Nicotinic acetylcholine receptors (nAChR) can be found throughout the human nervous system. The receptors regulate a multitude of functions, including development, inflammation, and movement. They also serve as the receptor ...

Flavopiridol is a promising therapeutic agent currently under phase I and phase II clinical investigation for the treatment of Chronic Lymphocytic Leukemia (CLL) and other hematologic and solid tumor malignancies. Flavopiridol ...

Background: Prescription compliance is a complex issue, affected by physical, psychological, and emotional factors. Changes in color vision due to the normal aging process are an aspect of declining physical functioning ...

There are conflicting interpretations as to how many populations of dopamine storage vesicles exist in the nerve terminals of dopaminergic neurons. The goal of this project is to develop a computer simulation model of a ...

Leishmaniasis, a disease caused by protozoan parasites of the genus Leishmania, affects millions of people worldwide [6]. Without effective treatment, visceral leishmaniasis is associated with a near 100% fatality rate, ...

ABSTRACT Background: A survey was developed to gather information from both pharmacists and patients with epilepsy on the issue of antiepileptic drug formulation switching. This study looked at the patient-focused issues ...

This project has investigated the effects of inhibition of the dopamine transporter on extracellular dopamine when dopaminergic neurons are electrically paced at rates substantially higher than those occurring in the brain. ...