Abstract: Native chemical ligation (NCL) is a method used to synthesize a covalent bond between two proteins. The method has been extensively used to react a C-terminal thioester on one protein with an N-terminal cysteine ...

Watercress, Nasturtium officinale W.T. Aiton, a member of the Brassicaceae family[1], is highly consumed in salad mixes and contains many phytochemicals[2]. As part of the cancer chemoprevention drug discovery program, ...

Nicotinic acetylcholine receptors (nAChR) can be found throughout the human nervous system. The receptors regulate a multitude of functions, including development, inflammation, and movement. They also serve as the receptor ...

This study investigates antibiotic efficacy against planktonic vs biofilm bacteria in vitro, using eight different antibiotics: carbenicillin, ciprofloxacin, colistin, gentamicin, meropenem, rifampicin, tobramycin, and ...

We propose a study to evaluate the impact of health information exchange between the community pharmacist and the epilepsy clinic. We will recruit 50 patients with epilepsy from our clinic to be in this 6-month pilot ...

Pathophysiological conditions such as cerebral ischemia (stroke) trigger the production of new neurons in the hippocampus dentate gyrus. The functional significance of ischemia-induced neurogenesis is believed to be the ...

Experience has demonstrated that when epilepsy patients are given advice about changes to their drug regimen, a portion follow it. The objective of this cross-sectional study was to determine why epilepsy patients do or ...

Stimulation of glutamatergic tone has been causally linked to myocardial pathogenesis and amplified systemic blood pressure (BP). Memantine, a non-competitive N-Methyl-D-aspartate glutamatergic receptor (NMDA-R) antagonist, ...

Leishmaniasis is a parasitic disease with a high incidence of infection and, in some cases, the potential to be fatal. This disease is largely entrenched in poverty, making access to effective and inexpensive diagnoses, ...

Dopamine D2 antagonist antipsychotic drugs share the effects of increasing dopamine synthesis, dopamine neuron firing rate, and dopamine and DOPAC levels. These antagonists all raise extracellular dopamine to approximately ...