The synthesis of GdB-texaphyrins as novel multipurpose cancer drugs
Jordan, Sarah (2009-06)
Texaphyrins are a synthetic class of porphyrin analogues that contain a metal atom complexed at their centers. This class of compounds selectively accumulates in cancer cells, thus creating a promising opportunity for ...
Single Nucleotide Polymorphism in BCRP and Effects on Flavopiridol Transport
Tran, Linda (2008-06)
Flavopiridol is a promising therapeutic agent currently under phase I and phase II clinical investigation for the treatment of Chronic Lymphocytic Leukemia (CLL) and other hematologic and solid tumor malignancies. Flavopiridol ...
The effects of age-related changes in color vision on the ability of older adults to properly take medication
Skomrock, Lindsay (2008-06)
Background: Prescription compliance is a complex issue, affected by physical, psychological, and emotional factors. Changes in color vision due to the normal aging process are an aspect of declining physical functioning ...
Computational Simulations of Dopaminergic Varicosities Suggest Two Sources of DOPAC Rather Than Two Populations of Dopamine Storage Vesicles
Hughes, Rachel (2008-06)
There are conflicting interpretations as to how many populations of dopamine storage vesicles exist in the nerve terminals of dopaminergic neurons. The goal of this project is to develop a computer simulation model of a ...
In Vitro Stability and Pharmacokinetics of Novel Antileishmanial Compounds
Becker, Kimberly (2007-06)
Leishmaniasis, a disease caused by protozoan parasites of the genus Leishmania, affects millions of people worldwide . Without effective treatment, visceral leishmaniasis is associated with a near 100% fatality rate, ...
An Assessment of Pharmacist & Patient Knowledge of and Attitudes Toward Reporting Adverse Drug Reactions in Patients with Epilepsy
Alyssa, Chen (2008-06)
ABSTRACT Background: A survey was developed to gather information from both pharmacists and patients with epilepsy on the issue of antiepileptic drug formulation switching. This study looked at the patient-focused issues ...
Computational Studies on Effects of Cocaine on Fast-paced Dopamine Neurons
Choksy, Achint Viral (2006-06)
This project has investigated the effects of inhibition of the dopamine transporter on extracellular dopamine when dopaminergic neurons are electrically paced at rates substantially higher than those occurring in the brain. ...
Synthesis of Thieno[2,3]-pyrimidines as Candidate Antileishmanial Agents
Tkacz, Victoria (2006-06)
Mechanistic Studies of Pentamidine Analogs on Leishmania donovani Promastigotes
Nzimiro, Sandra (2006-08)
EFFECT OF STRUCTURAL MODIFICATIONS OF ANTHRACYCLINE AGAINST DRUG-SENSITIVE AND RESISTANT CANCER CELLS
AIMIUWU, JOSEPHINE EKI (2005-06)
Purpose: Many anthracycline anticancer drugs contain carbohydrate moieties as a part of their chemical structure. Research studies have suggested that the sugar moiety of these anthracyclines play an important role in ...