Browsing Pharmacy Undergraduate Research Theses and Honors Research Theses by Issue Date
Now showing results 1-20 of 30
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Novel Selective Estrogen Receptor Modulator (SERM) OSU-ERβ-12 Demonstrates Anti-fibrotic Efficacy
Klein, Abigail ( 2020-12 )Purpose: Based on demonstrated ERβ-selective transcriptional activity in a cellular model, it was hypothesized that in vivo, efficacious doses of the novel ERβ agonist OSU-ERβ-12 could be determined that have minimal ... -
A Substituted Indole Scaffold as a Class of Allosteric HIV-1 Integrase Inhibitor
Bockbrader, Ross H. ( 2019-12 )Although a number of drugs have been developed and approved to combat HIV over the past 40 years, mutations of the virus and its protein targets have necessitated the continued discovery and design of even more novel ... -
Antibiotic Efficacy in Treating Variant Pseudomonas aeruginosa and Staphylococcus aureus Biofilms
Li, Anthony ( 2019-05 )This study investigates antibiotic efficacy against planktonic vs biofilm bacteria in vitro, using eight different antibiotics: carbenicillin, ciprofloxacin, colistin, gentamicin, meropenem, rifampicin, tobramycin, and ... -
Activity of Galeterone in Hepatocellular Carcinoma and Description of Androgen Receptor Expression in Mouse Liver
Mullins, Riley ( 2019-05 )Globally, liver cancer is the sixth most commonly diagnosed cancer, fourth leading cause of cancer deaths, and has increasing incidence and mortality rates. Hepatocellular carcinoma (HCC) is the dominant form of liver ... -
D-RING MODIFICATIONS OF THE PHYLLANTHUSMIN CLASS OF ARYLNAPHTHALENE LIGNAN NATURAL PRODUCTS
Ho, Aimee ( 2019-05 )Natural products isolated from plants of the Phyllanthus genus, specifically members of the arylnaphthalene subclass of lignan lactones, show promise as a potential treatment option for ovarian cancer. These compounds are ... -
Characterization of microRNAs as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Etoposide (VP-16) Resistant K562 Cells.
Kania, Evan ( 2019-05 )The enzyme DNA topoisomerase IIα (TOP2α) induces covalent complexes with DNA and produces transient double-strand DNA breaks crucial for processes such as replication and normal chromosomal dysjunction at mitosis. TOP2α ... -
Memantine, an NMDA Receptor Antagonist, Prevents Thyroxin-Induced Hypertension, but Not Cardiac Remodeling
Repas, Steven Joseph ( 2017-05 )Stimulation of glutamatergic tone has been causally linked to myocardial pathogenesis and amplified systemic blood pressure (BP). Memantine, a non-competitive N-Methyl-D-aspartate glutamatergic receptor (NMDA-R) antagonist, ... -
Identification of NF-κB Inhibitors from Watercress
Patel, Krishna ( 2013-05 )Watercress, Nasturtium officinale W.T. Aiton, a member of the Brassicaceae family[1], is highly consumed in salad mixes and contains many phytochemicals[2]. As part of the cancer chemoprevention drug discovery program, ... -
Mitogen and stress-activated protein kinase (MSK1/2) regulates ischemia-induced neurogenesis and morphological maturation
Yujia, Liu ( 2013-05 )Pathophysiological conditions such as cerebral ischemia (stroke) trigger the production of new neurons in the hippocampus dentate gyrus. The functional significance of ischemia-induced neurogenesis is believed to be the ... -
Bioactivity-Guided Fractionation of Taxodium distichum
Gromovsky, Anthony ( 2013-05 )Leishmaniasis is a parasitic disease with a high incidence of infection and, in some cases, the potential to be fatal. This disease is largely entrenched in poverty, making access to effective and inexpensive diagnoses, ... -
Antipsychotic Drugs Influence Dopamine Neuron Terminals via Action on D2-receptors and Vesicles
Klausing, Alex ( 2013-05 )Dopamine D2 antagonist antipsychotic drugs share the effects of increasing dopamine synthesis, dopamine neuron firing rate, and dopamine and DOPAC levels. These antagonists all raise extracellular dopamine to approximately ... -
Synthesis of Allosteric Modulators for Nicotinic Acetylcholine Receptors
Young, Jason ( 2012-06 )Nicotinic acetylcholine receptors (nAChR) can be found throughout the human nervous system. The receptors regulate a multitude of functions, including development, inflammation, and movement. They also serve as the receptor ... -
Evaluating decision-making in patients with epilepsy
Strazar, Abbey ( 2012-06 )Experience has demonstrated that when epilepsy patients are given advice about changes to their drug regimen, a portion follow it. The objective of this cross-sectional study was to determine why epilepsy patients do or ... -
A Semi-Synthetic Method for Sythesis of SUMOylated Hypoxia Inducible Factor-1 alpha for Future Functional Analysis
Heater, Bradley ( 2011-06 )Abstract: Native chemical ligation (NCL) is a method used to synthesize a covalent bond between two proteins. The method has been extensively used to react a C-terminal thioester on one protein with an N-terminal cysteine ... -
A Randomized, Controlled Study to Evaluate the Impact of Healthcare Information Exchange between Community Pharmacists and an Epilepsy Clinic
DeNiro, Eileen ( 2010-08 )We propose a study to evaluate the impact of health information exchange between the community pharmacist and the epilepsy clinic. We will recruit 50 patients with epilepsy from our clinic to be in this 6-month pilot ... -
The synthesis of GdB-texaphyrins as novel multipurpose cancer drugs
Jordan, Sarah ( 2009-06 )Texaphyrins are a synthetic class of porphyrin analogues that contain a metal atom complexed at their centers. This class of compounds selectively accumulates in cancer cells, thus creating a promising opportunity for ... -
Single Nucleotide Polymorphism in BCRP and Effects on Flavopiridol Transport
Tran, Linda ( 2008-06 )Flavopiridol is a promising therapeutic agent currently under phase I and phase II clinical investigation for the treatment of Chronic Lymphocytic Leukemia (CLL) and other hematologic and solid tumor malignancies. Flavopiridol ... -
The effects of age-related changes in color vision on the ability of older adults to properly take medication
Skomrock, Lindsay ( 2008-06 )Background: Prescription compliance is a complex issue, affected by physical, psychological, and emotional factors. Changes in color vision due to the normal aging process are an aspect of declining physical functioning ... -
Computational Simulations of Dopaminergic Varicosities Suggest Two Sources of DOPAC Rather Than Two Populations of Dopamine Storage Vesicles
Hughes, Rachel ( 2008-06 )There are conflicting interpretations as to how many populations of dopamine storage vesicles exist in the nerve terminals of dopaminergic neurons. The goal of this project is to develop a computer simulation model of a ... -
An Assessment of Pharmacist & Patient Knowledge of and Attitudes Toward Reporting Adverse Drug Reactions in Patients with Epilepsy
Alyssa, Chen ( 2008-06 )ABSTRACT Background: A survey was developed to gather information from both pharmacists and patients with epilepsy on the issue of antiepileptic drug formulation switching. This study looked at the patient-focused issues ...