Browsing Pharmacy Undergraduate Research Theses and Honors Research Theses by Issue Date

Preliminary in silico Docking Study with Selected FDA Approved Drugs for Neurological Disorders

Slemp, Khayla ( 2021-05 )

The current study focused on five FDA approved drugs that are prescribed to treat various neurological conditions. The drugs selected for the study include Memantine, Levodopa, Tetrabenazine, Gabapentin, Zolpidem. In silico ...

Quantitative Assays of Mismatch Repair Activity

Yu, Tiffany ( 2021-05 )

Defects in the human mismatch repair (MMR) genes are the cause of Lynch syndrome as well as 10-40% of sporadic colorectal, gastric, endometrial, ovarian, and upper urinary tract tumors. The MMR system recognizes and repairs ...

Novel Selective Estrogen Receptor Modulator (SERM) OSU-ERβ-12 Demonstrates Anti-fibrotic Efficacy

Klein, Abigail ( 2020-12 )

Purpose: Based on demonstrated ERβ-selective transcriptional activity in a cellular model, it was hypothesized that in vivo, efficacious doses of the novel ERβ agonist OSU-ERβ-12 could be determined that have minimal ...

A Substituted Indole Scaffold as a Class of Allosteric HIV-1 Integrase Inhibitor

Bockbrader, Ross H. ( 2019-12 )

Although a number of drugs have been developed and approved to combat HIV over the past 40 years, mutations of the virus and its protein targets have necessitated the continued discovery and design of even more novel ...

Antibiotic Efficacy in Treating Variant Pseudomonas aeruginosa and Staphylococcus aureus Biofilms

Li, Anthony ( 2019-05 )

This study investigates antibiotic efficacy against planktonic vs biofilm bacteria in vitro, using eight different antibiotics: carbenicillin, ciprofloxacin, colistin, gentamicin, meropenem, rifampicin, tobramycin, and ...

Activity of Galeterone in Hepatocellular Carcinoma and Description of Androgen Receptor Expression in Mouse Liver

Mullins, Riley ( 2019-05 )

Globally, liver cancer is the sixth most commonly diagnosed cancer, fourth leading cause of cancer deaths, and has increasing incidence and mortality rates. Hepatocellular carcinoma (HCC) is the dominant form of liver ...

D-RING MODIFICATIONS OF THE PHYLLANTHUSMIN CLASS OF ARYLNAPHTHALENE LIGNAN NATURAL PRODUCTS

Ho, Aimee ( 2019-05 )

Natural products isolated from plants of the Phyllanthus genus, specifically members of the arylnaphthalene subclass of lignan lactones, show promise as a potential treatment option for ovarian cancer. These compounds are ...

Characterization of microRNAs as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Etoposide (VP-16) Resistant K562 Cells.

Kania, Evan ( 2019-05 )

The enzyme DNA topoisomerase IIα (TOP2α) induces covalent complexes with DNA and produces transient double-strand DNA breaks crucial for processes such as replication and normal chromosomal dysjunction at mitosis. TOP2α ...

Memantine, an NMDA Receptor Antagonist, Prevents Thyroxin-Induced Hypertension, but Not Cardiac Remodeling

Repas, Steven Joseph ( 2017-05 )

Stimulation of glutamatergic tone has been causally linked to myocardial pathogenesis and amplified systemic blood pressure (BP). Memantine, a non-competitive N-Methyl-D-aspartate glutamatergic receptor (NMDA-R) antagonist, ...

Identification of NF-κB Inhibitors from Watercress

Patel, Krishna ( 2013-05 )

Watercress, Nasturtium officinale W.T. Aiton, a member of the Brassicaceae family[1], is highly consumed in salad mixes and contains many phytochemicals[2]. As part of the cancer chemoprevention drug discovery program, ...

Mitogen and stress-activated protein kinase (MSK1/2) regulates ischemia-induced neurogenesis and morphological maturation

Yujia, Liu ( 2013-05 )

Pathophysiological conditions such as cerebral ischemia (stroke) trigger the production of new neurons in the hippocampus dentate gyrus. The functional significance of ischemia-induced neurogenesis is believed to be the ...

Bioactivity-Guided Fractionation of Taxodium distichum

Gromovsky, Anthony ( 2013-05 )

Leishmaniasis is a parasitic disease with a high incidence of infection and, in some cases, the potential to be fatal. This disease is largely entrenched in poverty, making access to effective and inexpensive diagnoses, ...

Antipsychotic Drugs Influence Dopamine Neuron Terminals via Action on D2-receptors and Vesicles

Klausing, Alex ( 2013-05 )

Dopamine D2 antagonist antipsychotic drugs share the effects of increasing dopamine synthesis, dopamine neuron firing rate, and dopamine and DOPAC levels. These antagonists all raise extracellular dopamine to approximately ...

Synthesis of Allosteric Modulators for Nicotinic Acetylcholine Receptors

Young, Jason ( 2012-06 )

Nicotinic acetylcholine receptors (nAChR) can be found throughout the human nervous system. The receptors regulate a multitude of functions, including development, inflammation, and movement. They also serve as the receptor ...

Evaluating decision-making in patients with epilepsy

Strazar, Abbey ( 2012-06 )

Experience has demonstrated that when epilepsy patients are given advice about changes to their drug regimen, a portion follow it. The objective of this cross-sectional study was to determine why epilepsy patients do or ...

A Semi-Synthetic Method for Sythesis of SUMOylated Hypoxia Inducible Factor-1 alpha for Future Functional Analysis

Heater, Bradley ( 2011-06 )

Abstract: Native chemical ligation (NCL) is a method used to synthesize a covalent bond between two proteins. The method has been extensively used to react a C-terminal thioester on one protein with an N-terminal cysteine ...

A Randomized, Controlled Study to Evaluate the Impact of Healthcare Information Exchange between Community Pharmacists and an Epilepsy Clinic

DeNiro, Eileen ( 2010-08 )

We propose a study to evaluate the impact of health information exchange between the community pharmacist and the epilepsy clinic. We will recruit 50 patients with epilepsy from our clinic to be in this 6-month pilot ...