Calcium (Ca2+) is a ubiquitous 2nd messenger, known to regulate many cellular pathways including muscle contraction, cell proliferation, and apoptosis. Deregulation of Ca2+ homeostasis is thought to play a role in vascular ...

Vascular endothelial cell (EC) exposure to arterial-level fluid mechanical shear stress is known to cause an increase in cytosolic calcium levels ([Ca2+]c). The [Ca2+]c increase is mediated by both extracellular Ca2+ influx ...