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dc.contributor.advisorKokiko-Cochran, Olga
dc.creatorPalmer, Kelsey
dc.date.accessioned2022-04-21T21:53:14Z
dc.date.available2022-04-21T21:53:14Z
dc.date.issued2022-05
dc.identifier.urihttp://hdl.handle.net/1811/101343
dc.description.abstractTraumatic brain injury (TBI) impairs cognitive function of learning and memory, which can be worsened by post-TBI stressors. Many stressors cause sleep disturbances in the TBI population which leads us to use mechanical sleep fragmentation (SF) as a physiologically relevant approach to study the effects of stress after injury. We previously showed that post-TBI SF impairs cognitive function 30 days post injury (DPI). Therefore, we hypothesize that after a 30-day recovery period we will still see stress effects in learning and memory. To test this, we gave male and female mice a moderate lateral fluid percussion TBI or sham injury and left them undisturbed or exposed to SF daily for 30 DPI. Afterwards all mice were left undisturbed for an additional 30 DPI and Barnes maze testing was done during this recovery period. We found that there is an uncoupling of within and between day performance within the Barnes maze task for the sleep fragmentation recovery (SF-R) TBI group but no discrepancies otherwise for acquisition of this spatial task. SF-R, regardless of TBI, increased percent time in goal quadrant during the probe trial. We also found there to be higher activity of ∆FosB in the CA1 of Sham SF-R animals, indicating increased neuronal activity with sham SF-R but not TBI SF-R. Therefore, our data shows that while there is some evidence of persistent hippocampal deficits, overall, there are no robust lasting effects of chronic post-TBI SF following 30 days of recovery.en_US
dc.description.sponsorshipDepartment of Defense OKC NIH R01 JG NIH R01 OSU CBI Seed Granten_US
dc.language.isoenen_US
dc.publisherThe Ohio State Universityen_US
dc.relation.ispartofseriesThe Ohio State University. Department of Neuroscience Undergraduate Research Thesesen_US
dc.titleRecovery From Chronic Sleep Fragmentation after Traumatic Brain Injury Does Not Cause Lasting Deficits in Cognitive Behavioren_US
dc.typeThesisen_US
dc.description.embargoNo embargoen_US
dc.description.academicmajorAcademic Major: Neuroscienceen_US


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