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The Effects of Fermented Soy and Soy diets on Hepatic Lipid Composition in Zucker (fa/fa) Rats

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Title: The Effects of Fermented Soy and Soy diets on Hepatic Lipid Composition in Zucker (fa/fa) Rats
Creators: Cole, Rachel
Advisor: Belury, Martha
Issue Date: 2006-06
Abstract: Sixty million (30%) adults in the United States are considered obese. Obesity (Body Mass Index > 30 kg/m²) is an inflammatory disease that has its origin in diet. Obesity is the condition of accumulation of lipids in the adipose tissue and in non-adipose tissues such as the liver and muscle (eg. steatosis). The WHO-coordinated Cardiovascular Diseases and Alimentary Comparison Study (CARDIAC), a worldwide epidemiological study, found that those people who consumed soy had a significantly reduced risk of obesity than those who did not consume soy in their diets. The effects of fermented soy, soy, and casein diets on body weight of adipose mass and lipid composition of the liver in obese Zucker rats was studied. Thirty-nine male Zucker fatty rats, which are prone to hyperphagia, obesity, and insulin resistance, were randomized and placed in four groups, each group being fed a different diet. The diets were: 1) Casein diet (n=9); 2) Soy diet (n=10); 3) Fermented soy diet (n=10); 4) Mixture of soy and fermented soy (n=10). The differences in weight gain, food intake, changes in adipose mass and fat accumulation in the liver were examined. After feeding diets for ten weeks, the rats were euthanized and necropsy was performed. Weights of the removed organs were recorded. There were no effects of diets on food intake, body weight or adipose mass. All three soy diet groups had a significantly lower liver weight and liver to body weight ratio compared to the casein diet group. The casein diet group also had a significantly lower percentage of polyunsaturated fatty acids in the livers than both the soy and fermented soy diet groups. However, the casein diet group had a significantly higher percentage of monounsaturated fatty acids in the livers than all three of the soy diet groups. Both the fermented soy and soy diet groups had significantly higher amounts of omega-6 fatty acids in the livers than the casein diet group. Overall, fermented soy and soy diets did have an effect on hepatic lipid metabolism in Zucker fatty rats when compared to the casein diet.
Embargo:
Series/Report no.: The Ohio State University. Department of Human Nutrition Honors Theses; 2006
Keywords: soy
fermented soy
Lipids
Hepatic
Sponsors: Ajinomoto Inc, Tokyo
URI: http://hdl.handle.net/1811/6601
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