Vitamin supplementation effects on homocysteine and psychological functioning

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Title: Vitamin supplementation effects on homocysteine and psychological functioning
Creators: Trinidad, Marcy Camilla
Advisor: Emery, Charles
Issue Date: 2005-12
Abstract: Elevated homocysteine levels are associated with increased risk of heart disease. One possible strategy to reduce risk of heart disease is through reduction of homocysteine with vitamin B. Eighty middle-aged men and women participated in a four-week study examining vitamin supplementation effects. Pre-test measures consisted of the Beck Depression Inventory, Revised Life Orientation Test, Cohen’s Perceived Stress Scale, and an assessment of homocysteine. Post-test measures included the same battery of tests as well as the Profile of Mood States. Participants were randomly assigned to receive either the self-administered supplement consisting of 0.4 mg folate, 0.4 mg B12, and 10 mg B6 or a placebo. Data were analyzed with repeated measures analysis of variance with time (pre-test v. post-test) as a within-subjects factor and condition (vitamin v. placebo) as a between-subjects factor. With an alpha level of 0.05, no statistically significant effect of supplementation was found for depression, F (1, 80) = 2.27, p = 0.14 or homocysteine, F (1, 80) = 0.80, p = 0.37.
Series/Report no.: The Ohio State University. Department of Psychology Honors Theses; 2005
Keywords: Optimism
B vitamins
Vitamin B12
Vitamin B6
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