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Levoamphetamine and Dextroamphetamine: Differential Effect on Aggression and Hyperkinesis in Children and Dogs

Please use this identifier to cite or link to this item: http://hdl.handle.net/1811/51180

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Title: Levoamphetamine and Dextroamphetamine: Differential Effect on Aggression and Hyperkinesis in Children and Dogs
Creators: Arnold, L. Eugene; Kirilcuk, Vladimir; Corson, Samuel A.; Corson, Elizabeth O'L.
Issue Date: 1973
Publisher: American Psychiatric Publishing
Citation: L. Eugene Arnold et al, "Levoamphetamine and Dextroamphetamine: Differential Effect on Aggression and Hyperkinesis in Children and Dogs," The American Journal of Psychiatry 130, no. 2 (1973)
Abstract: In laboratory experiments with hyperkinetic, untrainable dogs and in a comparison of levoamphetamine, dextroamphetamine, and placebo in children, levoamphetamine and dextroamphetamine were found to be approximately equal in calming an aggressive, hostile dog and in benefiting "unsocialized-aggressive" children; dextroamphetamine was more effective than levoamphetamine in calming "nervousness" and hyperactivity in dogs and in overanxious-hyperkinetic children. These data suggest that in the hyperkinetic syndrome, aggression and hostility may be benefited equally by levoamphetamine or dextroamphetamine via a dopaminergic mechanism, while anxiety and overactivity may be benefited significantly only by the dextro isomer via a norepinephrinergic mechanism.
ISSN: 1535-7228
URI: http://hdl.handle.net/1811/51180
Rights: © 1973 American Psychiatric Publishing, Inc.
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