T-cell activation promotes tumorigenesis in inflammation-associated cancer

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dc.creator Rauch, Dan
dc.creator Gross, Shimon
dc.creator Harding, John
dc.creator Bokhari, Sirosh
dc.creator Niewiesk, Stefan
dc.creator Lairmore, Michael
dc.creator Piwnica-Worms, David
dc.creator Ratner, Lee
dc.date.accessioned 2010-12-14T15:18:45Z
dc.date.available 2010-12-14T15:18:45Z
dc.date.issued 2009-12-17
dc.identifier.citation Dan Rauch et al, "T-cell activation promotes tumorigenesis in inflammation-associated cancer," Retrovirology 6 (2009), doi:10.1186/1742-4690-6-116, http://www.retrovirology.com/content/6/1/116 en_US
dc.identifier.issn 1742-4690
dc.identifier.uri http://hdl.handle.net/1811/47382
dc.description.abstract Chronic inflammation has long been associated with a wide range of malignancies, is now widely accepted as a risk factor for development of cancer, and has been implicated as a promoter of a variety of cancers including hematopoietic malignancies. We have described a mouse model uniquely suited to examine the link between inflammation and lymphoma in which the Tax oncogene, expressed in activated T and NK cells, perpetuates chronic inflammation that begins as microscopic intraepithelial lesions and develops into inflammatory nodules, subcutaneous tumors, and large granular lymphocytic leukemia. The use of bioluminescent imaging in these mice has expanded our ability to interrogate aspects of inflammation and tumorigenesis non-invasively. Here we demonstrate that bioluminescence induction in these mice correlated with inflammation resulting from wounding, T cell activation, and exposure to chemical agents. In experiments in which long-term effects of inflammation on disease outcome were monitored, the development of lymphoma was promoted by an inflammatory stimulus. Finally we demonstrated that activation of T-cells in T-cell receptor (TCR) transgenic TAX-LUC animals dramatically exacerbated the development of subcutaneous TCR- CD16+ LGL tumors. The role of activated T-cells and acquired immunity in inflammation-associated cancers is broadly applicable to hematopoietic malignancies, and we propose these mice will be of use in dissecting mechanisms by which activated T-cells promote lymphomagenesis in vivo. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.title T-cell activation promotes tumorigenesis in inflammation-associated cancer en_US
dc.type Article en_US
dc.identifier.doi 10.1186/1742-4690-6-116
dc.identifier.osuauthor niewiesk.1
dc.identifier.osuauthor lairmore.1
dc.rights.cc Attribution 3.0 Unported en_US
dc.rights.ccuri http://creativecommons.org/licenses/by/3.0/ en_US
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Attribution 3.0 Unported