OSU Navigation Bar

The Ohio State University University Libraries Knowledge Bank

The Knowledge Bank is scheduled for regular maintenance on Sunday, April 20th, 8:00 am to 12:00 pm EDT. During this time users will not be able to register, login, or submit content.

USING DIFFERENTIAL ION MOBILITY AS A CONFORMATIONAL FILTER TO SIMPLIFY SPECTRA OF BIOMOLECULAR IONS

Please use this identifier to cite or link to this item: http://hdl.handle.net/1811/46153

Show full item record

Files Size Format View
abstract.gif 36.79Kb GIF image Thumbnail of USING DIFFERENTIAL ION MOBILITY AS A CONFORMATIONAL FILTER TO SIMPLIFY SPECTRA OF BIOMOLECULAR IONS

Title: USING DIFFERENTIAL ION MOBILITY AS A CONFORMATIONAL FILTER TO SIMPLIFY SPECTRA OF BIOMOLECULAR IONS
Creators: Rizzo, Thomas R.; Boyarkin, Oleg V.; Seaiby, Caroline; Papadopoulos, Georgios
Issue Date: 2010
Abstract: As one pushes spectroscopic studies to biological molecules of increasing size, the presence of multiple stable conformers with slightly different spectra can become a major source of spectral congestion. In such cases, the use of non-spectroscopic methods to separate different conformers could greatly simplify the electronic and vibrational spectra of large, flexible species. This talk will give an update on our work using Field Asymmetric Ion Mobility Spectrometry (FAIMS) as a conformational filter for biomolecular ions produced in the gas phase by electrospray. After conformational preselection by FAIMS, the ions are injected into a cold, 22-pole ion trap where their electronic spectrum reveals the remaining degree of conformational heterogeneity. We will present our most recent results using the nonapeptide bradykinin.
URI: http://hdl.handle.net/1811/46153
Other Identifiers: 2010-TB-11
Bookmark and Share