OSU Navigation Bar

The Ohio State University University Libraries Knowledge Bank

Photoperiodic Regulation of Affective Responses and Hippocampal Cell Morphology in Siberian Hamsters

Please use this identifier to cite or link to this item: http://hdl.handle.net/1811/45523

Show simple item record

Files Size Format View
JLWorkman_proceedings_paper.pdf 492.4Kb PDF View/Open

dc.contributor.advisor Nelson, Randy
dc.creator Workman, Joanna
dc.date.accessioned 2010-06-02T20:54:31Z
dc.date.available 2010-06-02T20:54:31Z
dc.date.issued 2010-05
dc.identifier.uri http://hdl.handle.net/1811/45523
dc.description Social and Behavioral Sciences; Social Work; Law: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum) en_US
dc.description.abstract Seasonal affective disorder (SAD) is characterized by depressive episodes during winter that are alleviated during summer and by morning bright light treatment. Currently, there is no animal model of SAD. However, it may be possible to use rodents that respond to day length to understand how day length can shape brain and behavior in humans. For instance, Siberian hamsters use day length to time seasonal cycles of reproduction and also exhibit changes in nonreproductive behaviors dependent on day length. Specifically, short-day Siberian hamsters increase floating in the forced swim test (a behavioral test used to screen antidepressant compounds). Current research in depression and animal models of depression suggests that hippocampal atrophy may underlie the symptoms of depression and depressive-like behaviors, respectively. The goal of this study was to determine whether altered depressive-like responses after exposure to short days are associated with photoperiod-mediated plasticity within the hippocampus of Siberian hamsters. Hamsters were housed in either short (8:16 LD) or long days (16:8 LD) for 10 weeks. At the end of 10 weeks hamsters were tested in the forced swim test and 48 h later, brains were removed and stained using the Golgi impregnation method. Brains were processed for hippocampal dendritic length, branching, and spines, as well as cell body size. Short days significantly reduced cell body size and dendritic complexity in the CA1 region of the hippocampus. This suggests that altered depressive-like behavior induced by exposure to short days may be a consequence of reduced complexity (and perhaps connectivity) in the hippocampus. en_US
dc.language.iso en_US en_US
dc.relation.ispartofseries 2010 Edward F. Hayes Graduate Research Forum. 24th en_US
dc.title Photoperiodic Regulation of Affective Responses and Hippocampal Cell Morphology in Siberian Hamsters en_US
dc.type Article en_US
dc.description.embargo No embargo en_US
dc.rights.cc Attribution-NonCommercial-NoDerivs 3.0 Unported en_US
dc.rights.ccuri http://creativecommons.org/licenses/by-nc-nd/3.0/ en_US
Attribution-NonCommercial-NoDerivs 3.0 Unported This item is licensed under a Creative Commons License:
Attribution-NonCommercial-NoDerivs 3.0 Unported