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Uptake and depletion of plasma 17α-methyltestosterone during induction of masculinization in muskellunge, Esox masquinongy: Effect on plasma steroids and sex reversal

Please use this identifier to cite or link to this item: http://hdl.handle.net/1811/36850

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dc.creator Rinchard, Jacques
dc.creator Dabrowski, Konrad
dc.creator Garcia-Abiado, Mary Ann
dc.creator Ottobre, Joseph
dc.date.accessioned 2009-05-13T12:12:45Z
dc.date.available 2009-05-13T12:12:45Z
dc.date.issued 1999
dc.identifier.citation Rinchard, Jacques; Dabrowski, Konrad; Garcia-Abiado, Mary Ann; Ottobre, Joseph "Uptake and depletion of plasma 17α-methyltestosterone during induction of masculinization in muskellunge, Esox masquinongy: Effect on plasma steroids and sex reversal," Steroids, v. 64, no. 8, 1999, pp. 518-525. en
dc.identifier.issn 0039-128X (print)
dc.identifier.uri http://hdl.handle.net/1811/36850
dc.description.abstract Oral administration of 17α-methyltestosterone (MT) was used to induce masculinization of sexually undifferentiated muskellunge, Esox masquinongy. Three groups of muskellunge (mean weight, 2.5 ± 0.6 g) were submitted to MT treatment (15 mg of MT/kg) for 60 days. An additional one group was used as a control (hormone-free diet). Food was distributed over a 10-h period by using automatic belt feeders. Blood was sampled in both control and treated fish at different intervals during and after feeding: before (0 h), at 3 h, 6 h, and cessation of feeding (10 h), and after a fast of 22 h (32 h). MT had no significant effect on growth and survival in muskellunge 6 months after the treatment. Concentrations of plasma MT increased during the feeding period and reached their maximum levels 6 or 10 h after starting feeding. This rapid increase of MT indicated a rapid absorption of this steroid. Plasma MT levels then declined and reached a radir by 22 h after cessation of feeding, suggesting that MT is rapidly metabolized and excreted. The profiles of plasma testosterone during the MT treatment did not differ significantly between control and MT-treated groups. During and after the MT treatment, the concentration of plasma testosterone did not differ significantly between control and MT-treated groups. Moreover, no sexual dimorphism of testosterone levels was observed. Six months after treatment, the sex ratio in MT-treated groups (33% males, 62% females, and 5% intersex) was opposite to control (70% and 30%, respectively) and differed significantly. This suggests that at 15 mg of MT/kg over 60 days, a paradoxical feminization took place. en
dc.description.sponsorship Salaries were partly provided by State and Federal Funds awarded to the Ohio Agriculture Research and Development Center, Wooster, OH, USA. en
dc.language.iso en_US en
dc.subject 17α-methyltestosterone (MT) en
dc.subject masculinization in muskellunge en
dc.subject sex reversal en
dc.subject plasma steroids en
dc.title Uptake and depletion of plasma 17α-methyltestosterone during induction of masculinization in muskellunge, Esox masquinongy: Effect on plasma steroids and sex reversal en
dc.type Article en