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Effect of Selected Amino Acid and Amino Sugar Derivatives on the Immune Response

Please use this identifier to cite or link to this item: http://hdl.handle.net/1811/22523

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dc.creator Lewis, Neil J. en_US
dc.creator Filppi, Joyce A. en_US
dc.creator Rheins, Melvin S. en_US
dc.date.accessioned 2006-07-07T01:41:10Z
dc.date.available 2006-07-07T01:41:10Z
dc.date.issued 1978-03 en_US
dc.identifier.citation The Ohio Journal of Science. v78, n2 (March, 1978), 100-102 en_US
dc.identifier.issn 0030-0950 en_US
dc.identifier.uri http://hdl.handle.net/1811/22523
dc.description Author Institution: Division of Medicinal Chemistry, College of Pharmacy, Department of Microbiology and Department of Microbiology, College of Biological Sciences, Ohio State Univ. en_US
dc.description.abstract The low molecular weight amino acids, N-a-benzyloxycarbonyl-L-lysine and L-lysine, and the amino sugar derivative, N-acetyl-D-glucosamine, were examined for effects on the immune response of mice to sheep erythrocytes. Treatment dosages of 1000, 100, 50 and 10 mg/kg of the test compounds did not alter the body weight, organ weight or peripheral leucocyte count of test mice. Mice given N-a-benzyloxycarbonyl- L-lysine demonstrated significant increases or decreases in the splenic plaqueforming cell response to sheep erythrocytes depending on the treatment regimen employed. Animals given N-acetyl-D-glucosamine showed an increase in the splenic plaque forming cell response while those receiving L-lysine had no detectable alteration. en_US
dc.format.extent 274337 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.title Effect of Selected Amino Acid and Amino Sugar Derivatives on the Immune Response en_US