Prediction of Survival Time of Rats in Hot Environments

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Title: Prediction of Survival Time of Rats in Hot Environments
Creators: Wright, G. L.; Knecht, E.; Lempert, B.
Issue Date: 1977-09
Citation: The Ohio Journal of Science. v77, n5 (September, 1977), 199-206
Abstract: A total of 136 male rats were exposed to terminal heat stress and the colonic heating curves were analyzed to determine equilibrium temperature, rate of heating from resting temperature to the equilibrium temperature, the difference between resting temperature and equilibrium temperature, and the rate of colonic temperature change during the first 30 minutes following attainment of the equilibrium temperature for formulation of an equation for prediction of survival time. It was determined by stepwise multiple linear regression that equilibrium temperature and rate of colonic temperature change were significantly correlated with survival time. A prediction equation was computed for control animals (N = 66) and applied to rats of different body weight (age), thermal exposure environment, and peripheral vascular tone (spontaneously hypertensive rats). The results indicated that the relationship between survival time and heating curve parameters was similar between different age groups with a mean error of 0.2% and 7.3% noted in predicted values for 10 and 7-week old animals, respectively. The predictive accuracy of the equation was, however, markedly reduced in control animals (36.2% error) and hypertensive animals (15.2% error) exposed to a less severe thermal environment.
Description: Author Institution: Physiology and Ergonomics Branch; Physical Agents Branch, NIOSH
ISSN: 0030-0950
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