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The Discocyte-Echinocyte Transformation as an Index of Human Red Cell Trauma

Please use this identifier to cite or link to this item: http://hdl.handle.net/1811/22399

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Title: The Discocyte-Echinocyte Transformation as an Index of Human Red Cell Trauma
Creators: Black, Keith L.; Jones, Richard D.
Issue Date: 1976-09
Citation: The Ohio Journal of Science. v76, n5 (September, 1976), 225-230
Abstract: Scanning electron microscopic observation of blood samples before, during and after cardiopulmonary bypass during cardiovascular surgery revealed that 4 to 25% of the red blood cells undergo a progressive transformation of discocyte to echinocyte. A morphological index, I, was developed and the change in I (Ir) was found to correlate well with measurements of free plasma hemoglobin. Incubation of blood samples form normal subjects for 90 minutes at 37°C resulted in no increase in Ir whereas incubated samples from patients following cardiopulmonary bypass showed an increased Ir to a mean value of 1140 ±185. Incubation therefore appears to uncover sublethal red cell damage caused by extracorporeal circulation. It is suggested that this technique is a sensitive index of red cell trauma which may have useful clinical applications.
URI: http://hdl.handle.net/1811/22399
ISSN: 0030-0950
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