Cellular Kinetics in Acute Leukemia

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dc.creator Mauer, Alvin M. en_US
dc.creator Lampkin, Beatrice C. en_US
dc.date.accessioned 2006-07-06T20:41:40Z
dc.date.available 2006-07-06T20:41:40Z
dc.date.issued 1973-01 en_US
dc.identifier.citation The Ohio Journal of Science. v73, n1 (January, 1973), 11-15 en_US
dc.identifier.issn 0030-0950 en_US
dc.identifier.uri http://hdl.handle.net/1811/21949
dc.description Author Institution: Department of Pediatrics, University of Cincinnati, and The Children's Hospital, and The Children's Hospital Research Foundation en_US
dc.description.abstract In most patients with acute leukemia, the generation time of leukemic cells is about (10 hours, longer than for normal cells. Approximate times for the phases of the cell cycle are: DNA synthesis (S), 20 hours; mitosis (M), 2 hours; and the post-synthesis and postmitosis rest phases (G2 and Gi), 2 and 36 hours, respectively. A most important finding has been that a variable proportion of leukemic cells are out of cycle, that is, are in a resting or Go state. These resting cells are in equilibrium with the dividing cells, and some, as yet unknown, control mechanism for leukemic-cell growth controls the flow of cells from one compartment to the other. A critical feature of the resting cells is that they are relatively resistant to cycle-dependent chemotherapeutic agents. Much information has been obtained concerning the effects of drugs on the proliferative characteristics of leukemic cells. This information provides the basis for designing regimens with better timing of drug administration and advantageous use of combined chemotherapy. en_US
dc.format.extent 467069 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.title Cellular Kinetics in Acute Leukemia en_US