Browsing by Subject "zebrafish"
Now showing results 1-5 of 5
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Characterization of glioma cell line characteristics via antibody labeling in an orthotopic zebrafish model
Jaros, Brian ( 2016-05 )Glioblastoma (GBM) is a highly aggressive form of brain cancer with limited efficacious treatments and thus a low survival time in patients. To further understand the biology of GBM tumors, we utilized immunohistochemistry ... -
Characterization of the effects of BTK inhibition and monocyte-produced IL-8 on the hematopoietic stem cell niche
Belardo, Alexander ( 2020-05 )Hematopoietic stem and progenitor cells (HSPCs) are multipotent stem cells that give rise to all blood cell lineages. During early zebrafish development, HSPCs interact closely with endothelial cells in an endothelial niche ... -
Identification of Rbfox-regulated transcripts important for muscle function
Zhao, Jinghan ( 2018-11-01 )Rbfox RNA-binding proteins are important regulators of muscle-specific splicing. Rbfox proteins contain an RNA recognition motif that is conserved from flies to human and binds to (U)GCAUG motifs that are enriched in introns ... -
The Role of Protein Kinase C Isozymes on the Zebrafish HSC Microenvironment
Deruelle, William ( 2020-12 )Long-lived hematopoietic stem cells (HSCs) are cells that self-renew and generate all mature blood cell types.1 HSCs reside in a microenvironment composed of multiple distinct cellular niches that provide critical signals ... -
The Role of the Rbfox Proteins in Zebrafish Muscle Development
Leist, Rachel ( 2014-05 )Tissue specific alternative splicing is essential to the proper function of genes in many pathways. Muscle development is largely affected by alternative splicing of muscle-specific exons. Defects in muscle-specific splicing ...