OSU Navigation Bar

The Ohio State University University Libraries Knowledge Bank

Chemical Carcinogenesis : Syntheses of 2,7-Bis- (Acetamido) Fluorenes with Increased Molecular Thickness by 9-Substitution

Please use this identifier to cite or link to this item: http://hdl.handle.net/1811/5580

Show full item record

Files Size Format View
V70N06_371.pdf 698.7Kb PDF View/Open

Title: Chemical Carcinogenesis : Syntheses of 2,7-Bis- (Acetamido) Fluorenes with Increased Molecular Thickness by 9-Substitution
Creators: Fishel, D. L.; Kletecka, G.; Muralidhara, R.
Issue Date: 1970-11
Citation: The Ohio Journal of Science. v70 n6 (November, 1970), 371-378
Abstract: The series: 9-methyl, 9-isopropyl, 9-cyclohexyl, 9,9-dimethyl, 9,9-diethyl, and the unsubstituted parent 2,7-bis (acetamido) fluorene were synthesized from the corresponding 9-substituted fluorenes. The two routes employed consisted of either (1) dinitration, reduction to the diamine, and diacetylation, or (2) Friedel-Crafts diacylation, then rearrangement via the Schmidt reaction. This provides a series of compounds of use in comparing relative carcinogenicity with changes in chemical reactivity as a function of increased steric hindrance due to altered molecular "thickness."
Description: Author Institution: Department of Chemistry, Kent State University, Kent, Ohio 44240
URI: http://hdl.handle.net/1811/5580
ISSN: 0030-0950
Rights: Reproduction of articles for non-commercial educational or research use granted without request if credit to The Ohio State University and The Ohio Academy of Science is given.
Bookmark and Share